Altered ARID1A expression in colorectal cancer.

Mehran ErfaniSeyed Vahid HosseiniMaral MokhtariMozhdeh ZamaniKamran TahmasebiMahvash Alizadeh NainiAlireza TaghaviJohn M CarethersMinoru KoiHassan BrimPooneh MokarramHassan Ashktorab

Published in: BMC cancer (2020)

ARID1A expression is downregulated in CRC tissues which correlates with it being a tumor suppressor protein. This finding confirms ARID1A loss of expression in CRC development. Our in-vitro results suggest high methylation status associates with reduced ARID1A expression and contributes to CRC tumorigenesis. However, there was no significant association between ARID1A loss of expression and clinicopathological characteristics. Future in-vivo analysis is warranted to further establish ARID1A role in colorectal neoplastic transformation.

Keyphrases

poor prognosis
binding protein
gene expression
long non coding rna
small molecule
protein protein