Fatty acid desaturase genetic variations and dietary omega-3 fatty acid intake associate with arterial stiffness.

Magnus BäckConstance XhaardRaphael RougetQuentin ThuillierOscar PlundeSusanna C LarssonNicolas GirerdJoão Pedro FerreiraJean-Marc BoivinErwan BozecLudovic MerckléFaiez ZannadAxelle HogeMichèle GuillaumeClaire Dandine-RoullandEdith Le FlochDelphine Bacq-DaianJean François DeleuzeLaurie Van den BergheJulie-Anne NazareMartine LavilleChristiane BranlantIsabelle Behm-AnsmantSandra WagnerPatrick Rossignol

Published in: European heart journal open (2022)

Taken together, these findings point to FADS1 genotype-dependent associations of omega-3 PUFA intake on subclinical cardiovascular disease. These findings may have implications for identifying responders and non-responders to omega-3 PUFA supplementation and open up for personalized dietary counselling in cardiovascular prevention.

Keyphrases

fatty acid
cardiovascular disease
blood pressure
weight gain
genome wide
gene expression
body mass index
copy number
weight loss