Early prevention of cognitive impairment in the community population: The Beijing Aging Brain Rejuvenation Initiative.
Caishui YangXin LiJunying ZhangYaojing ChenHe LiDongfeng WeiPeng LuYing LiangZhen LiuNi ShuFang WangQing GuanWuhai TaoQingshan WangJianjun JiaLin AiRuixue CuiYanping WangDantao PengWei ZhangKewei ChenXiaomin WangJizong ZhaoYongyan WangQi DongJun WangZhanjun Zhangnull nullPublished in: Alzheimer's & dementia : the journal of the Alzheimer's Association (2021)
Facing considerable challenges associated with aging and dementia, China urgently needs an evidence-based health-care system for prevention and management of dementia. The Beijing Aging Brain Rejuvenation Initiative (BABRI) is a community-based cohort study initiated in 2008 that focuses on asymptomatic stages of dementia, aims to develop community-based prevention strategies for cognitive impairment, and provides a platform for scientific research and clinical trials. Thus far, BABRI has recruited 10,255 participants (aged 50 and over, 60.3% female), 2021 of whom have been followed up at least once at a 2- or 3-year interval. This article presents aims and study design of BABRI; summarizes preliminary behavioral and neuroimaging findings on mild cognitive impairment (MCI) and results of clinical trials on MCI; and discusses issues concerning early prevention in community, MCI diagnosis methods, and applications of database of aging and dementia. BABRI is proposed to build a systematic framework on brain health in old age.
Keyphrases
- mild cognitive impairment
- cognitive impairment
- cognitive decline
- clinical trial
- healthcare
- mental health
- white matter
- resting state
- air pollution
- quality improvement
- public health
- randomized controlled trial
- particulate matter
- high throughput
- brain injury
- climate change
- health information
- electronic health record
- drug induced
- double blind