Transcribed Ultraconserved Regions in Cancer.
Myron K GibertAditya SarkarBilhan ChagariChristian Roig-LaboyShekhar SahaSylwia BednarekBenjamin KefasFarina HanifKadie HudsonCollin DubeYing ZhangRoger AbounaderPublished in: Cells (2022)
Transcribed ultraconserved regions are putative lncRNA molecules that are transcribed from DNA that is 100% conserved in human, mouse, and rat genomes. This is notable, as lncRNAs are typically poorly conserved. TUCRs remain very understudied in many diseases, including cancer. In this review, we summarize the current literature on TUCRs in cancer with respect to expression deregulation, functional roles, mechanisms of action, and clinical perspectives.