Identification of a potent and selective LAPTc inhibitor by RapidFire-Mass Spectrometry, with antichagasic activity.

Maikel IzquierdoDe LinSandra O'NeillLauren A WebsterChristy PatersonJohn ThomasMirtha Elisa AguadoEnrique Colina AraújoDaniel Alpízar-PedrazaHalimatu JojiLorna MacLeanAnthony HopeDavid W GrayMartin ZoltnerMark C FieldJorge González-BacerioManu De Rycker

Published in: PLoS neglected tropical diseases (2024)

Our data indicates that these new LAPTc inhibitors should be considered for further development as antiparasitic agents for the treatment of Chagas disease.

Keyphrases

mass spectrometry
electronic health record
liquid chromatography
big data
high resolution
machine learning
high performance liquid chromatography
capillary electrophoresis
anti inflammatory
ms ms
data analysis
bioinformatics analysis
tandem mass spectrometry