Manu De Rycker

Scopus Author ID Scopus Author ID Scopus Author ID ORCID

Publication Activity (10 Years)

Years Active: 2017-2024
Publications (10 Years): 30

Top Venues

PLoS neglected tropical diseases

PloS one

Journal of medicinal chemistry

ACS infectious diseases

University of Dundee

This page only lists publications with an associated author ORCID identifier.

Affiliation History

University of Dundee Sep 01 2018

United Kingdom

Research :: Drug Discovery Unit

Publications

Lorna M MacLean, Mark Ariyanayagam, Lalitha Sastry, Christy Paterson, Manu De Rycker, Alan H Fairlamb
Validation of Trypanosoma cruzi inactivation techniques for laboratory use. PloS one 19 (4) (2024)
Lorna M MacLean, Mark Ariyanayagam, Lalitha Sastry, Christy Paterson, Manu De Rycker, Alan H Fairlamb
Validation of Trypanosoma cruzi inactivation techniques for laboratory use. PloS one 19 (4) (2024)
Maikel Izquierdo, De Lin, Sandra O'Neill, Lauren A Webster, Christy Paterson, John Thomas, Mirtha Elisa Aguado, Enrique Colina Araújo, Daniel Alpízar-Pedraza, Halimatu Joji, Lorna MacLean, Anthony Hope, David W Gray, Martin Zoltner, Mark C Field, Jorge González-Bacerio, Manu De Rycker
Identification of a potent and selective LAPTc inhibitor by RapidFire-Mass Spectrometry, with antichagasic activity. PLoS neglected tropical diseases 18 (2) (2024)
Maikel Izquierdo, De Lin, Sandra O'Neill, Lauren A Webster, Christy Paterson, John Thomas, Mirtha Elisa Aguado, Enrique Colina Araújo, Daniel Alpízar-Pedraza, Halimatu Joji, Lorna MacLean, Anthony Hope, David W Gray, Martin Zoltner, Mark C Field, Jorge González-Bacerio, Manu De Rycker
Identification of a potent and selective LAPTc inhibitor by RapidFire-Mass Spectrometry, with antichagasic activity. PLoS neglected tropical diseases 18 (2) (2024)
Lorna M MacLean, Mark Ariyanayagam, Lalitha Sastry, Christy Paterson, Manu De Rycker, Alan H Fairlamb
Validation of Trypanosoma cruzi inactivation techniques for laboratory use. PloS one 19 (4) (2024)
Lorna M MacLean, Mark Ariyanayagam, Lalitha Sastry, Christy Paterson, Manu De Rycker, Alan H Fairlamb
Validation of Trypanosoma cruzi inactivation techniques for laboratory use. PloS one 19 (4) (2024)
Lorna M MacLean, Mark Ariyanayagam, Lalitha Sastry, Christy Paterson, Manu De Rycker, Alan H Fairlamb
Validation of Trypanosoma cruzi inactivation techniques for laboratory use. PloS one 19 (4) (2024)
Maikel Izquierdo, De Lin, Sandra O'Neill, Lauren A Webster, Christy Paterson, John Thomas, Mirtha Elisa Aguado, Enrique Colina Araújo, Daniel Alpízar-Pedraza, Halimatu Joji, Lorna MacLean, Anthony Hope, David W Gray, Martin Zoltner, Mark C Field, Jorge González-Bacerio, Manu De Rycker
Identification of a potent and selective LAPTc inhibitor by RapidFire-Mass Spectrometry, with antichagasic activity. PLoS neglected tropical diseases 18 (2) (2024)
Maikel Izquierdo, De Lin, Sandra O'Neill, Lauren A Webster, Christy Paterson, John Thomas, Mirtha Elisa Aguado, Enrique Colina Araújo, Daniel Alpízar-Pedraza, Halimatu Joji, Lorna MacLean, Anthony Hope, David W Gray, Martin Zoltner, Mark C Field, Jorge González-Bacerio, Manu De Rycker
Identification of a potent and selective LAPTc inhibitor by RapidFire-Mass Spectrometry, with antichagasic activity. PLoS neglected tropical diseases 18 (2) (2024)
Laura A T Cleghorn, Richard J Wall, Sébastien Albrecht, Stuart A MacGowan, Suzanne Norval, Manu De Rycker, Andrew Woodland, Daniel Spinks, Stephen Thompson, Stephen Patterson, Victoriano Corpas Lopez, Gourav Dey, Iain T Collie, Irene Hallyburton, Robert Kime, Frederick R C Simeons, Laste Stojanovski, Julie A Frearson, Paul G Wyatt, Kevin D Read, Ian H Gilbert, Susan Wyllie
Development of a 2,4-Diaminothiazole Series for the Treatment of Human African Trypanosomiasis Highlights the Importance of Static-Cidal Screening of Analogues. Journal of medicinal chemistry (2023)
Michael G Thomas, Kate McGonagle, Paul Rowland, David A Robinson, Peter G Dodd, Isabel Camino-Díaz, Lorna Campbell, Juan Cantizani, Pablo Castañeda, Daniel Conn, Peter D Craggs, Darren Edwards, Liam Ferguson, Andrew Fosberry, Laura Frame, Panchali Goswami, Xiao Hu, Justyna Korczynska, Lorna MacLean, J Julio Martin, Nicole Mutter, Maria Osuna-Cabello, Christy Paterson, Imanol Peña, Erika G Pinto, Caterina Pont, Jennifer Riley, Yoko Shishikura, Frederick R C Simeons, Laste Stojanovski, John Thomas, Karolina Wrobel, Robert J Young, Filip Zmuda, Fabio Zuccotto, Kevin D Read, Ian H Gilbert, Maria Marco, Timothy J Miles, Pilar Manzano, Manu De Rycker
Structure-Guided Design and Synthesis of a Pyridazinone Series of Trypanosoma cruzi Proteasome Inhibitors. Journal of medicinal chemistry (2023)
Silvia González, Richard J Wall, John Thomas, Stéphanie Braillard, Gino Brunori, Isabel Camino, Juan Cantizani, Sandra Carvalho, Pablo Castañeda Casado, Eric Chatelain, Ignacio Cotillo, Jose M Fiandor, Amanda Fortes Francisco, David Grimsditch, Martine Keenan, John M Kelly, Albane Kessler, Chiara Luise, Jonathan J Lyon, Lorna M MacLean, Maria Marco, J Julio Martin, María Santos Martínez, Christy Paterson, Kevin D Read, Angel Santos-Villarejo, Fabio Zuccotto, Susan Wyllie, Timothy J Miles, Manu De Rycker
Short-course combination treatment for experimental chronic Chagas disease. Science translational medicine 15 (726) (2023)
Manu De Rycker
Comment on "The translational challenge in Chagas disease drug development" by Kratz et al. Memorias do Instituto Oswaldo Cruz 117 (2022)
Manu De Rycker, Susan Wyllie, David Horn, Kevin D Read, Ian H Gilbert
Anti-trypanosomatid drug discovery: progress and challenges. Nature reviews. Microbiology (2022)
Nina Svensen, Susan Wyllie, David W Gray, Manu De Rycker
Live-imaging rate-of-kill compound profiling for Chagas disease drug discovery with a new automated high-content assay. PLoS neglected tropical diseases 15 (10) (2021)
Michael G Thomas, Stephen Brand, Manu De Rycker, Fabio Zuccotto, Iva Lukac, Peter G Dodd, Eun-Jung Ko, Sujatha Manthri, Kate McGonagle, Maria Osuna-Cabello, Jennifer Riley, Caterina Pont, Frederick Simeons, Laste Stojanovski, John Thomas, Stephen Thompson, Elisabet Viayna, Jose M Fiandor, J Julio Martin, Paul G Wyatt, Timothy J Miles, Kevin D Read, Maria Marco, Ian H Gilbert
Scaffold-Hopping Strategy on a Series of Proteasome Inhibitors Led to a Preclinical Candidate for the Treatment of Visceral Leishmaniasis. Journal of medicinal chemistry 64 (9) (2021)
Michael G Thomas, Manu De Rycker, Myriam Ajakane, Sabrinia D Crouch, Lorna Campbell, Alain Daugan, Gloria Fra, César Guerrero, Claire J Mackenzie, Lorna MacLean, Sujatha Manthri, Franck Martin, Suzanne Norval, Maria Osuna-Cabello, Jennifer Riley, Yoko Shishikura, Juan Miguel-Siles, Frederick R C Simeons, Laste Stojanovski, John Thomas, Stephen Thompson, Raul F Velasco, Jose M Fiandor, Paul G Wyatt, Kevin D Read, Ian H Gilbert, Timothy J Miles
Identification of 6-amino-1H-pyrazolo[3,4-d]pyrimidines with in vivo efficacy against visceral leishmaniasis. RSC medicinal chemistry 11 (10) (2020)
Michael G Thomas, Manu De Rycker, Richard J Wall, Daniel Spinks, Ola Epemolu, Sujatha Manthri, Suzanne Norval, Maria Osuna-Cabello, Stephen Patterson, Jennifer Riley, Frederick R C Simeons, Laste Stojanovski, John Thomas, Stephen Thompson, Claire Naylor, Jose M Fiandor, Paul G Wyatt, Maria Marco, Susan Wyllie, Kevin D Read, Timothy J Miles, Ian H Gilbert
Identification and Optimization of a Series of 8-Hydroxy Naphthyridines with Potent In Vitro Antileishmanial Activity: Initial SAR and Assessment of In Vivo Activity. Journal of medicinal chemistry 63 (17) (2020)
Leah S Torrie, David A Robinson, Michael G Thomas, Judith V Hobrath, Sharon M Shepherd, John M Post, Eun-Jung Ko, Rafael Alves Ferreira, Claire J Mackenzie, Karolina Wrobel, Darren P Edwards, Ian H Gilbert, David W Gray, Alan H Fairlamb, Manu De Rycker
Discovery of an Allosteric Binding Site in Kinetoplastid Methionyl-tRNA Synthetase. ACS infectious diseases 6 (5) (2020)
Richard J Wall, Sandra Carvalho, Rachel Milne, Juan A Bueren-Calabuig, Sonia Moniz, Juan Cantizani-Perez, Lorna MacLean, Albane Kessler, Ignacio Cotillo, Lalitha Sastry, Sujatha Manthri, Stephen Patterson, Fabio Zuccotto, Stephen Thompson, Julio Martin, Maria Marco, Timothy J Miles, Manu De Rycker, Michael G Thomas, Alan H Fairlamb, Ian H Gilbert, Susan Wyllie
The Qi Site of Cytochrome b is a Promiscuous Drug Target in Trypanosoma cruzi and Leishmania donovani. ACS infectious diseases 6 (3) (2020)
Filip Zmuda, Lalitha Sastry, Sharon M Shepherd, Deuan Jones, Alison Scott, Peter D Craggs, Alvaro Cortes, David W Gray, Leah S Torrie, Manu De Rycker
Identification of Novel Trypanosoma cruzi Proteasome Inhibitors Using a Luminescence-Based High-Throughput Screening Assay. Antimicrobial agents and chemotherapy 63 (9) (2019)
Susan Wyllie, Stephen Brand, Michael Thomas, Manu De Rycker, Chun-Wa Chung, Imanol Pena, Ryan P Bingham, Juan A Bueren-Calabuig, Juan Cantizani, David Cebrian, Peter D Craggs, Liam Ferguson, Panchali Goswami, Judith Hobrath, Jonathan Howe, Laura Jeacock, Eun-Jung Ko, Justyna Korczynska, Lorna MacLean, Sujatha Manthri, Maria S Martinez, Lydia Mata-Cantero, Sonia Moniz, Andrea Nühs, Maria Osuna-Cabello, Erika Pinto, Jennifer Riley, Sharon Robinson, Paul Rowland, Frederick R C Simeons, Yoko Shishikura, Daniel Spinks, Laste Stojanovski, John Thomas, Stephen Thompson, Elisabet Viayna Gaza, Richard J Wall, Fabio Zuccotto, David Horn, Michael A J Ferguson, Alan H Fairlamb, Jose M Fiandor, Julio Martin, David W Gray, Timothy J Miles, Ian H Gilbert, Kevin D Read, Maria Marco, Paul G Wyatt
Preclinical candidate for the treatment of visceral leishmaniasis that acts through proteasome inhibition. Proceedings of the National Academy of Sciences of the United States of America 116 (19) (2019)
Manu De Rycker, David Horn, Bree Aldridge, Richard K Amewu, Clifton E Barry, Frederick S Buckner, Sarah Cook, Michael A J Ferguson, Nathalie Gobeau, Jennifer Herrmann, Paul Herrling, William Hope, Jennifer Keiser, Maria Jose Lafuente-Monasterio, Paul D Leeson, Didier Leroy, Ujjini H Manjunatha, James McCarthy, Timothy J Miles, Valerie Mizrahi, Olena Moshynets, Jacquin Niles, John P Overington, John Pottage, Srinivasa P S Rao, Kevin D Read, Isabela Ribeiro, Lynn L Silver, Jen Southern, Thomas Spangenberg, Shyam Sundar, Caitlin Taylor, Wes Van Voorhis, Nicholas J White, Susan Wyllie, Paul G Wyatt, Ian H Gilbert
Setting Our Sights on Infectious Diseases. ACS infectious diseases 6 (1) (2019)
Filip Zmuda, Sharon M Shepherd, Michael A J Ferguson, David W Gray, Leah S Torrie, Manu De Rycker
Trypanosoma cruzi Phosphomannomutase and Guanosine Diphosphate-Mannose Pyrophosphorylase Ligandability Assessment. Antimicrobial agents and chemotherapy 63 (10) (2019)
Leah S Torrie, Fabio Zuccotto, David A Robinson, David W Gray, Ian H Gilbert, Manu De Rycker
Identification of inhibitors of an unconventional Trypanosoma brucei kinetochore kinase. PloS one 14 (5) (2019)
Victoriano Corpas-Lopez, Sonia Moniz, Michael Thomas, Richard J Wall, Leah S Torrie, Dorothea Zander-Dinse, Michele Tinti, Stephen Brand, Laste Stojanovski, Sujatha Manthri, Irene Hallyburton, Fabio Zuccotto, Paul G Wyatt, Manu De Rycker, David Horn, Michael A J Ferguson, Joachim Clos, Kevin D Read, Alan H Fairlamb, Ian H Gilbert, Susan Wyllie
Pharmacological Validation of N-Myristoyltransferase as a Drug Target in Leishmania donovani. ACS infectious diseases 5 (1) (2018)
Lorna M MacLean, John Thomas, Michael D Lewis, Ignacio Cotillo, David W Gray, Manu De Rycker
Development of Trypanosoma cruzi in vitro assays to identify compounds suitable for progression in Chagas' disease drug discovery. PLoS neglected tropical diseases 12 (7) (2018)
Michael G Thomas, Manu De Rycker, Myriam Ajakane, Sébastian Albrecht, Ana Isabel Álvarez-Pedraglio, Markus Boesche, Stephen Brand, Lorna Campbell, Juan Cantizani-Perez, Laura A T Cleghorn, Royston C B Copley, Sabrinia D Crouch, Alain Daugan, Gerard Drewes, Santiago Ferrer, Sonja Ghidelli-Disse, Silvia Gonzalez, Stephanie L Gresham, Alan P Hill, Sean J Hindley, Rhiannon M Lowe, Claire J MacKenzie, Lorna MacLean, Sujatha Manthri, Franck Martin, Juan Miguel-Siles, Van Loc Nguyen, Suzanne Norval, Maria Osuna-Cabello, Andrew Woodland, Stephen Patterson, Imanol Pena, Maria Teresa Quesada-Campos, Iain H Reid, Charlotte Revill, Jennifer Riley, Jose Ramon Ruiz-Gomez, Yoko Shishikura, Frederick R C Simeons, Alasdair Smith, Victoria C Smith, Daniel Spinks, Laste Stojanovski, John Thomas, Stephen Thompson, Tim Underwood, David W Gray, Jose M Fiandor, Ian H Gilbert, Paul G Wyatt, Kevin D Read, Timothy J Miles
Identification of GSK3186899/DDD853651 as a Preclinical Development Candidate for the Treatment of Visceral Leishmaniasis. Journal of medicinal chemistry 62 (3) (2018)
Stephen Brand, Eun Jung Ko, Elisabet Viayna, Stephen Thompson, Daniel Spinks, Michael Thomas, Lars Sandberg, Amanda F Francisco, Shiromani Jayawardhana, Victoria C Smith, Chimed Jansen, Manu De Rycker, John Thomas, Lorna MacLean, Maria Osuna-Cabello, Jennifer Riley, Paul Scullion, Laste Stojanovski, Frederick R C Simeons, Ola Epemolu, Yoko Shishikura, Sabrinia D Crouch, Tania S Bakshi, Christopher J Nixon, Iain H Reid, Alan P Hill, Tim Z Underwood, Sean J Hindley, Sharon A Robinson, John M Kelly, Jose M Fiandor, Paul G Wyatt, Maria Marco, Timothy J Miles, Kevin D Read, Ian H Gilbert
Discovery and Optimization of 5-Amino-1,2,3-triazole-4-carboxamide Series against Trypanosoma cruzi. Journal of medicinal chemistry 60 (17) (2017)
Leah S Torrie, Stephen Brand, David A Robinson, Eun Jung Ko, Laste Stojanovski, Frederick R C Simeons, Susan Wyllie, John Thomas, Lucy Ellis, Maria Osuna-Cabello, Ola Epemolu, Andrea Nühs, Jennifer Riley, Lorna MacLean, Sujatha Manthri, Kevin D Read, Ian H Gilbert, Alan H Fairlamb, Manu De Rycker
Chemical Validation of Methionyl-tRNA Synthetase as a Druggable Target in Leishmania donovani. ACS infectious diseases 3 (10) (2017)

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Publication Activity (10 Years)

Top Topics

Top Venues

Manu De Rycker