Expression of aromatase in the rostral ventromedial medulla and its role in the regulation of visceral pain.

Po GaoXiao-Wei DingLi DongPing LuoGuo-Hua ZhangWei-Fang Rong

Published in: CNS neuroscience & therapeutics (2017)

Our observations confirmed the expression of aromatase in the RVM, a pivotal brain region in descending modulation of pain and opioid analgesia. The results support the hypothesis that locally produced estrogens in the RVM may be involved in the maintenance of chronic visceral hyperalgesia and the downstream signaling may involve phosphorylation of MOR.

Keyphrases

pain management
chronic pain
poor prognosis
neuropathic pain
insulin resistance
binding protein
postoperative pain
spinal cord
spinal cord injury
long non coding rna
resting state
metabolic syndrome
protein kinase
prefrontal cortex
functional connectivity