Human Leukocyte Antigens class II (HLA II) gene profile from an admixed population of patients with type 1 diabetes with severe diabetic retinopathy: a nested case-control study in Brazil.
Deborah Conte SantosLuís Cristóvão PortoMarcela Haas PizarroLaura Gomes Nunes de MeloDayse A SilvaRomulo Vianna OliveiraAnna Paula VillelaLuiza Harcar MunizCamila SoaresLucianne Righeti Monteiro TannusKarla Rezende Guerra DrummondAndré Araújo PinheiroFelipe MallmannFranz Schubert Lopes LealFernando Korn MalerbiPaulo Henrique MoralesMarília Brito GomesPublished in: Diabetology & metabolic syndrome (2021)
Our study showed no influence of HLA genes on the development of DR. Further longitudinal data is needed to better understand the role of genetic factors on this multifactorial significant microvascular complication.
Keyphrases
- diabetic retinopathy
- genome wide
- endothelial cells
- optical coherence tomography
- copy number
- genome wide identification
- dna methylation
- electronic health record
- early onset
- big data
- pluripotent stem cells
- genome wide analysis
- machine learning
- transcription factor
- bioinformatics analysis
- immune response
- artificial intelligence
- case control