Predictive Performance of Pharmacokinetic Model-Based Virtual Trials of Vancomycin in Neonates: Mathematics Matches Clinical Observation.

Bu-Fan YaoYue-E WuBo-Hao TangGuo-Xiang HaoEvelyne Jacqz-AigrainJohn van den AnkerWei Zhao

Published in: Clinical pharmacokinetics (2022)

The pharmacokinetic model-based virtual trials of vancomycin exhibited good predictive performance for dose-exposure relationships in neonates. These results might be used to assist the optimization of dosing regimens in neonatal practice, avoiding the need for trial and error.

Keyphrases

methicillin resistant staphylococcus aureus
low birth weight
primary care
healthcare
study protocol
clinical trial
phase iii
preterm infants
staphylococcus aureus
randomized controlled trial
quality improvement