Adjuvant effect of antimicrobial photodynamic therapy (aPDT) in the treatment of diabetic foot ulcers: A case series.
Rita de Cassia FerreiraRebeca Boltes CecattoSilvana Torres PerezRaquel Agnelli Mesquita-FerrariSandra Kalil BussadoriCinthya Cosme Gutierrez DuranAnna Carolina Ratto Tempestine HorlianaKristianne Porta Santos FernandesPublished in: Journal of biophotonics (2024)
This study aimed to evaluate the clinical evolution of patients with diabetic foot ulcer treated with antimicrobial photodynamic therapy (aPDT) using the Bates-Jensen (BJ) scale. A total of 21 patients were monitored, with an average age of 58 years. Patients underwent the standard treatment protocol of the institution, supplemented with aPDT utilizing 0.01% methylene blue (MB) and laser irradiation (660 nm, 100 mW, 6 J per point). Following aPDT, the lesions were protected with hydrofiber dressings containing silver. The Bates-Jensen Scale was employed at pre-treatment and post-aPDT sessions to assess lesion progression. The results demonstrated a significant difference between pre- and post-treatment values in the overall BJ score. The use of MB in aPDT proved to be an effective, safe, well-tolerated treatment with high patient adherence and the potential for implementation in the care of diabetic foot conditions.
Keyphrases
- photodynamic therapy
- end stage renal disease
- randomized controlled trial
- chronic kidney disease
- type diabetes
- ejection fraction
- early stage
- gold nanoparticles
- risk assessment
- palliative care
- peritoneal dialysis
- insulin resistance
- combination therapy
- high resolution
- skeletal muscle
- mass spectrometry
- replacement therapy
- human health
- patient reported