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STK3 kinase activation inhibits tumor proliferation through FOXO1-TP53INP1/P21 pathway in esophageal squamous cell carcinoma.

Ziying ZhaoYuan ChuAnqi FengShihan ZhangHao WuZhaoxing LiMingchuang SunLi ZhangTao ChenMeidong Xu
Published in: Cellular oncology (Dordrecht, Netherlands) (2024)
STK3 kinase has a high expression level in ESCC and can be activated by cellular ROS, inhibiting cell proliferation and migration. Additionally, STK3 activation-mediated FOXO1 regulates ESCC cell apoptosis and cell cycle arrest by targeting TP53INP1/P21. Our research underscores the anti-tumor function of STK3 in ESCC and elucidates the mechanism underlying its anti-tumor effect on ESCC.
Keyphrases
  • signaling pathway
  • pi k akt
  • cell cycle arrest
  • cell death
  • transcription factor
  • cell proliferation
  • poor prognosis
  • protein kinase
  • single cell
  • tyrosine kinase
  • dna damage
  • cell therapy
  • mesenchymal stem cells