Tricistronic expression of MOAP-1, Bax and RASSF1A in cancer cells enhances chemo-sensitization that requires BH3L domain of MOAP-1.

Yong Hoi LeeSiew Wai PangEsther Revai LechtichKhalid ShahSamson Eugin SimonSuriyan PonnusamyRamesh NarayananChit Laa PohKuan-Onn Tan

Published in: Journal of cancer research and clinical oncology (2020)

Expression of MBR in cancer cells induces apoptotic cell death with enhanced chemo-sensitization requiring the BH3L domain of MOAP-1. In animal model, the expression of MBR significantly reduces the growth of tumors, suggesting that MBR is a potent apoptotic sensitizer with potential therapeutic benefits for cancer treatment.

Keyphrases

cell death
poor prognosis
binding protein
anti inflammatory
combination therapy
drug delivery
locally advanced
rectal cancer