Mitochondria and pathogen immunity: from killer to firestarter.
Joel S RileyStephen W G TaitPublished in: The EMBO journal (2019)
Serving as an innate defence mechanism, invading pathogens elicit a broad inflammatory response in cells. In this issue, Brokatzky et al (2019) report that pathogens can cause activation of BAX/BAK which permeabilises a limited number of mitochondria. Induction of DNA damage, or release of mtDNA, triggers STING-dependent pro-inflammatory cytokine expression and secretion, revealing an unexpected role for the mitochondrial apoptotic machinery in immune defence.
Keyphrases
- cell death
- induced apoptosis
- oxidative stress
- dna damage
- cell cycle arrest
- inflammatory response
- gram negative
- immune response
- poor prognosis
- endoplasmic reticulum stress
- reactive oxygen species
- antimicrobial resistance
- endoplasmic reticulum
- lipopolysaccharide induced
- signaling pathway
- mitochondrial dna
- dna repair
- copy number
- candida albicans
- lps induced
- dna methylation
- binding protein
- anti inflammatory
- gene expression