Therapy-Induced Changes in CXCR4 Expression in Tumor Xenografts Can Be Monitored Noninvasively with N-[11C]Methyl-AMD3465 PET.

S V HartimathO DraghiciuT DaemenH W NijmanA van WaardeR A J O DierckxErik F J de Vries

Published in: Molecular imaging and biology (2021)

This study demonstrates the feasibility of N-[11C]methyl-AMD3465 PET imaging to monitor treatment-induced changes in the density of CXCR4 receptors in tumors and justifies further evaluation of CXCR4 as a potential imaging biomarker for evaluation of anti-tumor therapies.

Keyphrases

pet imaging
cell migration
positron emission tomography
poor prognosis
high resolution
computed tomography
age related macular degeneration
pet ct
binding protein
human health
risk assessment
combination therapy
mass spectrometry