Comparing neoadjuvant therapy followed by local excision to total mesorectal excision in the treatment of early stage rectal cancer: a systematic review and meta-analysis of randomised clinical trials.
Paul LynchOdhrán K RyanMark DonnellyÉanna J RyanMatthew G DaveyIan S ReynoldsBen CreavinAnn HanlyRory KennellySeán T MartinDes C WinterPublished in: International journal of colorectal disease (2023)
NAT + LE reduces adverse effects of TME, without any compromise in oncological outcomes, and the potential for an organ preserving strategy should be discussed with patients with T2-3N0 rectal cancers prior to treatment.
Keyphrases
- rectal cancer
- clinical trial
- locally advanced
- early stage
- open label
- randomized controlled trial
- type diabetes
- lymph node
- skeletal muscle
- metabolic syndrome
- mesenchymal stem cells
- weight loss
- minimally invasive
- bone marrow
- sentinel lymph node
- cell therapy
- double blind
- phase ii
- replacement therapy
- adverse drug
- childhood cancer