m6A-induced lncRNA RP11 triggers the dissemination of colorectal cancer cells via upregulation of Zeb1.

Yingmin WuXiangling YangZhuojia ChenLin TianGuanmin JiangFeng ChenJiexin LiPanpan AnLinlin LuNan LuoJun DuHong ShanHuanliang LiuHong-Sheng Wang

Published in: Molecular cancer (2019)

m6A-induced lncRNA RP11 can trigger the dissemination of CRC cells via post-translational upregulation of Zeb1. Considering the high and specific levels of RP11 in CRC tissues, our present study paves the way for further investigations of RP11 as a predictive biomarker or therapeutic target for CRC.

Keyphrases

long non coding rna
poor prognosis
high glucose
epithelial mesenchymal transition
diabetic rats
induced apoptosis
cell proliferation
signaling pathway
gene expression
drug induced
oxidative stress
long noncoding rna
endothelial cells