Targeting the dependence on PIK3C3-mTORC1 signaling in dormancy-prone breast cancer cells blunts metastasis initiation.
Islam E ElkholiAmélie RobertCamille MaloufHellen KuasneStanislav DrápelaGraham MacLeodSteven HébertAlain PacisVirginie CalderonClaudia L KleinmanAna P GomesJulio A Aguirre-GhisoMorag ParkStephane AngersJean-François CôtéPublished in: bioRxiv : the preprint server for biology (2024)
We reveal that dormancy-prone breast cancer cells depend on the class III PI3K to mediate a constant peripheral lysosomal positioning and mTORC1 hyperactivity. Targeting this pathway might blunt breast cancer metastasis.