Apremilast Normalizes Gene Expression of Inflammatory Mediators in Human Keratinocytes and Reduces Antigen-Induced Atopic Dermatitis in Mice.

Peter H SchaferMary AdamsGerald HoranFrancesca TruzziAlessandra MarconiCarlo Pincelli

Published in: Drugs in R&D (2020)

PDE4 is overexpressed in AD skin compared with normal skin, and inflammatory gene expression by human keratinocytes and mouse dermatitis can be modulated by apremilast.

Keyphrases

gene expression
endothelial cells
atopic dermatitis
wound healing
dna methylation
high glucose
induced pluripotent stem cells
oxidative stress
pluripotent stem cells
soft tissue
skeletal muscle