Investigation on the metabolic characteristics of isobavachin in Psoralea corylifolia L. (Bu-gu-zhi) and its potential inhibition against human cytochrome P450s and UDP-glucuronosyltransferases.
Han XingJing YangKaidi RenZifei QinPeile WangXiaojian ZhangZhi-Hong YaoFrank J GonzalezXinsheng YaoPublished in: The Journal of pharmacy and pharmacology (2020)
CYP1A2, 2C19 and UGT1As play an important role in isobavachin metabolism. Isobavachin demonstrated broad-spectrum inhibition of CYPs and UGTs.
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