Mechanistic Modeling of the Effect of Recombinant Human Hyaluronidase (rHuPH20) on Subcutaneous Delivery of Cetuximab in Rats.

Xizhe GaoJongbong LeeKiran DeshpandeDavid W KangAnas M FathallahLeonid Kagan

Published in: Pharmaceutical research (2022)

Proposed model can serve as a potential translational framework for capturing the effect of rHuPH20 across multiple preclinical species and in human studies and can be used for optimization of SC delivery of biotherapeutics.

Keyphrases

recombinant human
endothelial cells
pluripotent stem cells
metastatic colorectal cancer
human health
locally advanced