Systemic Inflammation in Metabolic Syndrome: Increased Platelet and Leukocyte Activation, and Key Role of CX3CL1/CX3CR1 and CCL2/CCR2 Axes in Arterial Platelet-Proinflammatory Monocyte Adhesion.
Patrice MarquesAida ColladoSergio Martinez-HervasElena DomingoEsther BenitoLaura PiquerasJosé T RealJuan F AscasoMaria-Jesus SanzPublished in: Journal of clinical medicine (2019)
We provide evidence of generalized immune activation in metabolic syndrome. Additionally, CX3CL1/CX3CR1 or CCL2/CCR2 axes are potential candidates for therapeutic intervention in cardiovascular disorders in metabolic syndrome patients, as their blockade impairs the augmented arterial platelet-Mon1 monocyte aggregate adhesiveness, which is a key event in atherogenesis.
Keyphrases
- metabolic syndrome
- dendritic cells
- end stage renal disease
- insulin resistance
- uric acid
- randomized controlled trial
- ejection fraction
- newly diagnosed
- chronic kidney disease
- cardiovascular risk factors
- endothelial cells
- peripheral blood
- regulatory t cells
- liver fibrosis
- liver injury
- prognostic factors
- peritoneal dialysis
- escherichia coli
- risk assessment
- cystic fibrosis
- immune response
- patient reported outcomes