Efficacy and tolerability of zinc acetate for treatment of chronic refractory cough: pilot randomised futility trial.

Aparna BalasubramanianJanet T HolbrookBrendan J Canning Loretta G QueMario CastroBarry J MakeLinda RogersMichael F BuskAlexis ReaAshley Alesia McCookJiaxian HeMeredith C McCormackRobert A Wise

Published in: ERJ open research (2023)

We observed no benefit of zinc therapy over placebo on cough symptoms or quality of life and conclude that larger trials of zinc for chronic cough are not warranted.

Keyphrases

study protocol
open label
oxide nanoparticles
phase iii
double blind
clinical trial
placebo controlled
phase ii
randomized controlled trial
sleep quality
depressive symptoms
mesenchymal stem cells