High-dose adenosine versus saline-induced cardioplegic arrest in coronary artery bypass grafting: A randomized double-blind clinical feasibility trial.
Mikko S MattilaKati M JärveläTimo T RinneKjell C NikusMarkku J RantanenJuho A A SiltanenJenna-Juulia HeleäJari Olavi LaurikkaPublished in: Scandinavian journal of surgery : SJS : official organ for the Finnish Surgical Society and the Scandinavian Surgical Society (2022)
A high dose adenosine bolus at the beginning of the first cardioplegia infusion resulted in significantly faster asystole in coronary artery bypass grafting patients but enhanced only partially the ventricular performance.EudraCT number: 2014-001382-26. https://www.clinicaltrialsregister.eu/ctr-search/trial/2014-001382-26/FI.
Keyphrases
- coronary artery bypass grafting
- high dose
- percutaneous coronary intervention
- coronary artery disease
- low dose
- phase iii
- clinical trial
- study protocol
- phase ii
- end stage renal disease
- stem cell transplantation
- ejection fraction
- chronic kidney disease
- double blind
- newly diagnosed
- heart failure
- acute coronary syndrome
- prognostic factors
- left ventricular
- randomized controlled trial
- open label
- high glucose
- protein kinase
- cell cycle
- patient reported outcomes
- endothelial cells
- cell proliferation
- oxidative stress