The identification and verification of hub genes associated with pulmonary arterial hypertension using weighted gene co-expression network analysis.
Weibin WuAi ChenSiming LinQiuran WangGuili LianLi LuoLiang-Di XiePublished in: BMC pulmonary medicine (2022)
PNISR and HNRNPH1 were potential biomarkers to diagnosis PAH. In summary, the identified DEGs, modules, pathways, and hub genes provide clues and shed light on the potential molecular mechanisms of PAH.
Keyphrases
- network analysis
- pulmonary arterial hypertension
- bioinformatics analysis
- genome wide identification
- genome wide
- pulmonary artery
- pulmonary hypertension
- polycyclic aromatic hydrocarbons
- poor prognosis
- copy number
- genome wide analysis
- dna methylation
- transcription factor
- binding protein
- human health
- risk assessment
- computed tomography
- coronary artery
- magnetic resonance
- climate change