Rh(III)-Catalyzed Dienylation and Cyclopropylation of 1,2,3-Benzotriazinones with Alkylidenecyclopropanes.

Yan-Zhi LiuYao-Fu ZengJiaohang WeiLin XiaoBing ShuJia-Lin SongWen-Xuan ZouDan-Ting ShenShao-Yong ChenYi-Chuan ZhengShang-Shi Zhang

Published in: Organic letters (2023)

Rh (III)-catalyzed dienylation and cyclopropylation of 1,2,3-benzotriazinones with alkylidenecyclopropanes (ACPs) has been achieved. Different from the previous reports of 1,2,3-benzotriazinones, the triazinone ring remained intact in this C-H bond functionlization reaction. Also, the denitrogenative cyclopropylation could also be realized by changing the reaction temperature. This protocol is featured with high E selectivity, wide substrate scope, and divergent structures of products.

Keyphrases

room temperature
randomized controlled trial
electron transfer
high resolution
structural basis
adverse drug
transition metal