GPR116 receptor regulates the antitumor function of NK cells via Gαq/HIF1α/NF-κB signaling pathway as a potential immune checkpoint.

Dandan GuoChenxu JinYaoxin GaoHaizhen LinLi ZhangYing ZhouJie YaoYixin DuanYaojun RenXinhui HuiYujia GeRenzheng YangWenzheng Jiang

Published in: Cell & bioscience (2023)

Our data indicated that GPR116 receptor had a negatively effect on NK cell function and downregulation of GPR116 receptor in NKG2D-CAR-NK92 cells could enhance the antitumor activity, which provides a new idea to enhance the antitumor efficiency of CAR NK cell therapy.

Keyphrases

nk cells
signaling pathway
cell therapy
fatty acid
pi k akt
stem cells
epithelial mesenchymal transition
mesenchymal stem cells
cell proliferation
oxidative stress
endothelial cells
binding protein
induced apoptosis
bone marrow
inflammatory response
human health
toll like receptor