Clinicopathological and prognostic significance of caveolin-1 and ATG4C expression in the epithelial ovarian cancer.

Yuyang ZengMengxi ChenSridha GaneshShunze HuHonglei Chen

Published in: PloS one (2020)

Decreased expression of CAV1 mRNA and increased expression of ATG4C mRNA in EOC can predict poor overall survival. The expression levels of CAV1 protein in stromal cells and ATG4C protein in cancer cells are significantly associated with histologic subtypes of EOC. These findings suggest that CAV1 and ATG4C serve as useful prognostic biomarkers and candidate therapeutic targets in EOC.

Keyphrases

poor prognosis
binding protein
long non coding rna
protein protein
small molecule