Enrichment of IGF-1R and PPARγ signalling pathways in orbital inflammatory diseases: steps toward understanding pathogenesis.

Rohan VermaDongseok ChoiAllison J ChenChristina A HarringtonDavid J WilsonHans E GrossniklausRoger A DaileyJohn NgEric A SteeleStephen R PlanckBobby S KornDon KikkawaCraig N CzyzJill A FosterMichael KazimGerald J HarrisDeepak P EdwardHaila Al-HussainAzza M Y MaktabiChris AlabiadArmando GarciaJames T Rosenbaum

Published in: The British journal of ophthalmology (2021)

Although OID includes a heterogenous group of pathologies, TAO, GPA, sarcoidosis and NSOI share enrichment of common gene signalling pathways, namely IGF-1R, PPARγ, adipocytokine and AMPK. Pathway analyses of gene expression suggest that other forms of orbital inflammation in addition to TAO may benefit from blockade of IGF-1R signalling pathways.

Keyphrases

gene expression
oxidative stress
pi k akt
binding protein
insulin resistance
growth hormone
dna methylation
genome wide
type diabetes
copy number
fatty acid
metabolic syndrome
signaling pathway
transcription factor
protein kinase
genome wide identification