Non-Keratinizing Nasopharyngeal Carcinoma with Adenomatous Differentiation.
Fredrik PeterssonPublished in: Head and neck pathology (2018)
A case of non-keratinizing, EBV-positive (EBER-in situ hybridization), carcinoma with adenomatous differentiation is presented. The patient is a 40 year old male with T2N2M0 disease who received standard combined chemo- and radiotherapy with complete resolution of all tumor. The tumor cells were strongly positive for low-molecular weight cytokeratins (AE1-3) and scattered cells expressed cytokeratin 20. No expression of cytokeratin 5/6, 7, p63, TTF-1, CDX2 or androgen receptor was detected. There was no evidence of recurrence or disease progression on follow-up after 19 months, which included post treatment MRI and PET-CT scans.
Keyphrases
- pet ct
- induced apoptosis
- contrast enhanced
- poor prognosis
- locally advanced
- magnetic resonance imaging
- computed tomography
- cell cycle arrest
- positron emission tomography
- early stage
- combination therapy
- case report
- squamous cell carcinoma
- cell death
- oxidative stress
- magnetic resonance
- radiation induced
- binding protein
- single molecule
- signaling pathway
- cancer therapy
- diffusion weighted imaging
- cell proliferation
- free survival
- pi k akt
- smoking cessation