Regulation role of CRTC3 in skeletal muscle and adipose tissue.
Jiaqi LiuZiye XuWeiche WuYizhen WangTizhong ShanPublished in: Journal of cellular physiology (2017)
The cyclic adenosine monophosphate (cAMP)-protein kinase A (PKA) signaling pathway plays important role in regulating energy homeostasis. Many of the effects of the cAMP-PKA signaling is mediated through the cAMP responsive element binding protein (CREB) and its coactivator CREB-regulated transcription coactivators (CRTCs). CRTC3 is a member of CRTCs family proteins and plays important roles in glucose and energy metabolism. Previous studies show that global knockout of CRTC3 enhances oxygen consumption and energy expenditure and subsequently protects the knockout animal against obesity. In skeletal muscle, CRTC3 affects lipid and glycogen metabolism and mitochondrial biogenesis. In white adipocytes, CRTC3 regulates GLUT4 expression and glucose uptake. More recently, the localization and function of CRTC3 in brown fat have been reported. In this review, we mainly discuss the regulatory role of CRTC3 in skeletal muscle and adipose tissues.
Keyphrases
- skeletal muscle
- insulin resistance
- adipose tissue
- binding protein
- protein kinase
- signaling pathway
- high fat diet
- high fat diet induced
- metabolic syndrome
- transcription factor
- type diabetes
- poor prognosis
- weight loss
- blood glucose
- gene expression
- weight gain
- body mass index
- epithelial mesenchymal transition
- physical activity
- cancer therapy
- glycemic control