Poor outcome in postpartum breast cancer patients is associated with distinct molecular and immunological features.

Hanne Lefrère Kat S Moore Giuseppe Floris Joyce Sanders Iris M Seignette Tycho Bismeijer Dennis Peters Annegien Broeks Erik Hooijberg Kristel Van Calsteren Patrick Neven Ellen Warner Fedro Alessandro Peccatori Sibylle Loibl Charlotte Maggen Sileny N Han Katarzyna J Jerzak Daniela Annibali Diether Lambrechts Karin E de Visser Lodewyk F A Wessels Liesbeth Lenaerts Frédéric Amant

Published in: Clinical cancer research : an official journal of the American Association for Cancer Research (2023)

These data point to the importance of plasma B-cells in the post-weaning mammary tumor microenvironment regarding the poor prognosis of PP-BCPW patients. Future prospective and in-depth research needs to further explore the role of B-cell immunobiology in this specific group of young breast cancer patients.

Keyphrases

poor prognosis
long non coding rna
end stage renal disease
ejection fraction
newly diagnosed
chronic kidney disease
prognostic factors
mechanical ventilation
machine learning
patient reported outcomes
big data
middle aged
single molecule