Pharmacokinetics of anti-TB drugs in children and adolescents with drug-resistant TB: a multicentre observational study from India.

Hemanth Kumar Agibothu KupparamIra ShahPadmapriyadarsini ChandrasekaranSushant ManeSangeeta SharmaBharathi Raja ThangaveluSudha VilvamaniVijayakumar AnnaviSanthana Mahalingam MahalingamKannan ThiruvengadamPoorna Gangadevi NavaneethapandianSrushti GandhiVishrutha PoojariZahabiya NalwallaVikas OswalPrathiksha GiridharanSarath Balaji BabuSridhar RathinamAsha FrederickSuhbangi MankarShanmugam Murugaiha Jeyakumar

Published in: The Journal of antimicrobial chemotherapy (2024)

Age significantly impacted the plasma concentration and exposure of moxifloxacin. The observed frequencies of suboptimal and supratherapeutic concentrations underscore the necessity for dose optimization and therapeutic drug monitoring in children and adolescents undergoing DR-TB treatment.

Keyphrases

drug resistant
mycobacterium tuberculosis
multidrug resistant
acinetobacter baumannii
clinical trial
study protocol
randomized controlled trial
combination therapy
pseudomonas aeruginosa
drug induced