Association of polycyclic aromatic hydrocarbon metabolite concentration in urine and occupational stress in underground coal miners in China: propensity score and bayesian kernel machine regression.

This study intends to examine the association of urinary monohydroxyl PAHs (OH-PAHs) concentration and occupational stress in coal miners. We sampled 671 underground coal miners from Datong, China, assessed their occupational stress using the Occupational Stress Inventory-Revised edition (OSI-R), and categorized them into the high stress miners and controls based on that. We determined urinary OH-PAHs concentration using ultrahigh performance liquid chromatography-tandem mass spectrometry, and analyzed its association with occupational stress using multiple linear regression, covariate balancing generalized propensity score (CBGPS), and Bayesian kernel machine regression (BKMR). The low molecular weight (LMW) OH-PAHs in quartile or homologue was significantly positively associated with Occupational Role Questionnaire (ORQ) and Personal Strain Questionnaire (PSQ) score, but was not associated with Personal Resources Questionnaire (PRQ) score. The OH-PAHs concentration was positively associated with ORQ and PSQ scores in coal miners, particularly the LMW OH-PAHs. Non-association was found in the OH-PAHs with PRQ score.