Outcomes of acute lymphoblastic leukaemia in adolescent and young adult Korean patients.
Young Ae KimHee Young JuHyeon Jin ParkNa Young LeeHyun Jeong LeeHyewon LeeHaryeom GhangPublished in: British journal of haematology (2019)
This study used Korean national data to investigate the relationship between treatment patterns and outcomes in Korean adolescent and young-adult (AYA) acute lymphoblastic leukaemia (ALL) patients. Chemotherapy incorporating L-asparaginase was considered paediatric-inspired (PI), as opposed to adult protocols. In total, 65·3% of patients received PI therapy. Five-year overall survival (OS) of PI-treated patients outperformed adult protocols (63·1% vs. 40·4%; P < 0·0001); this trend was maintained within various age subgroups. Younger age, L-asparaginase therapy, and radiotherapy corresponded with superior OS by multivariable analysis. OS tends to improve with PI protocols that include L-asparaginase in AYA ALL, suggesting that therapy protocol is critical in the treatment performance of this group.
Keyphrases
- end stage renal disease
- newly diagnosed
- young adults
- ejection fraction
- chronic kidney disease
- prognostic factors
- peritoneal dialysis
- randomized controlled trial
- mental health
- intensive care unit
- liver failure
- metabolic syndrome
- squamous cell carcinoma
- patient reported outcomes
- skeletal muscle
- weight loss
- adipose tissue
- electronic health record
- insulin resistance
- hepatitis b virus
- childhood cancer
- patient reported
- aortic dissection
- data analysis