Recognition that an individual's job could affect the likelihood of contracting coronavirus disease 2019 created challenges for investigators who sought to understand and prevent the transmission of severe acute respiratory syndrome coronavirus 2. Considerable research resources were devoted to separating the effects of occupational from nonoccupational risk factors. This commentary highlights results from studies that adjusted for multiple nonoccupational risk factors while estimating the effects of occupations and occupational risk factors. Methods used in these studies will prove useful in future infectious disease epidemics and pandemics and may potentially enrich studies of other occupational infectious and noninfectious respiratory diseases.