The Porirua Protocol in the Treatment of Clozapine-Induced Gastrointestinal Hypomotility and Constipation: A Pre- and Post-Treatment Study.

Susanna Every-PalmerPete M EllisMike NowitzJames StanleyEve GrantMark HuthwaiteHelen Dunn

Published in: CNS drugs (2018)

Treating clozapine-treated patients with docusate and senna augmented by macrogol appears effective in reducing CTTs in clozapine-induced constipation. Randomised controlled trials are the next step. Australian New Zealand Clinical Trial Registry ACTRN12616001405404 (registered retrospectively).

Keyphrases

clinical trial
high glucose
randomized controlled trial
oxidative stress
drug induced
endothelial cells
study protocol
replacement therapy
smoking cessation
phase ii