Philadelphia-Like Genetic Rearrangements in Adults With B-Cell ALL: Refractoriness to Chemotherapy and Response to Tyrosine Kinase Inhibitor in ABL Class Rearrangements.
Jayastu SenapatiElias J JabbourMarina Y KonoplevaNicholas James ShortGuillin TangNaval G DaverPartow KebriaeiTapan Mahendra KadiaNaveen PemmarajuKoichi TakahashiCourtney D D DiNardoKoiji SasakiGautam BorthakurBeenu ThakralRashmi Kanagal-ShamanaKeyur Pravinchandra PatelFarhad RavandiKathryn G RobertsCharles G MullighanHagop M KantarjianNitin JainPublished in: JCO precision oncology (2023)
Understanding the genomics of B-cell ALL is important for disease prognostication and for precise treatment planning. Besides conventional cytogenetics and directed FISH testing, multiplex fusion assays can help identify recurrent chromosomal translocations that are seen in patients with Ph-like ALL. Early initiation of TKI appears beneficial; larger studies are required to fully understand the benefit of TKI and to design rational combination therapies for these patients.