Altered interaction between enteric glial cells and mast cells in the colon of women with irritable bowel syndrome.

Felipe Meira de-FariaMaite Casado-BedmarCarl Mårten LindqvistMichael P JonesSusanna A WalterÅsa V Keita

Published in: Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society (2021)

Findings suggest the involvement of EGC and MC in the control of barrier function in the human colon and indicate a potential EGC-MC interaction that seems altered in IBS, with detrimental consequences to colonic permeability. Altogether, results suggest that imbalanced EGC-MC communication contributes to the pathophysiology of IBS.

Keyphrases

irritable bowel syndrome
endothelial cells
induced apoptosis
cell cycle arrest
endoplasmic reticulum stress
pluripotent stem cells
oxidative stress
spinal cord
signaling pathway
cell proliferation
risk assessment
human health