Secreted Protein Profiling of Human Aortic Smooth Muscle Cells Identifies Vascular Disease Associations.
Rédouane AherrahrouFerheen BaigKonstantinos TheofilatosDillon LueAlicia BeeleTiit ÖrdMinna U KaikkonenZouhair AherrahrouQi ChengSaikat Kumar B GhoshSantosh KarnewarVaishnavi KarnewarAloke V FinnGary K OwensMichael JonerManuel MayrMete CivelekPublished in: Arteriosclerosis, thrombosis, and vascular biology (2024)
Our results unravel the SMC proteome signature associated with vascular disorders, which may help identify potential therapeutic targets to accelerate the pathway to translation.
Keyphrases
- endothelial cells
- aortic valve
- genome wide
- induced pluripotent stem cells
- left ventricular
- single cell
- protein protein
- pulmonary artery
- pluripotent stem cells
- heart failure
- gene expression
- risk assessment
- binding protein
- dna methylation
- amino acid
- climate change
- atrial fibrillation
- pulmonary hypertension
- aortic dissection