The effects of sugar in drinking water on Streptococcus pyogenes colonisation in a murine nasopharyngeal infection model.
Farina Nor HashimiJulie BennettMichael G BakerNicole J MorelandTroy L MerryJacelyn Mei San LohPublished in: Scientific reports (2022)
The number of sugar-sweetened beverages consumed per day has been associated with an increased risk of acute rheumatic fever, an autoimmune disease triggered by superficial Streptococcus pyogenes infection. To explore if there could be a biological basis for this association, we used a mouse model of S. pyogenes nasopharyngeal colonisation combined with a dietary intervention. We observed an increased bacterial load in the nasopharynx of mice receiving sucrose drinking water post-infection, suggesting that high sucrose intake promotes S. pyogenes growth and/or survival. This provides new insight into the potential biological basis behind the association seen in humans.
Keyphrases
- drinking water
- health risk
- health risk assessment
- mouse model
- randomized controlled trial
- biofilm formation
- rheumatoid arthritis
- candida albicans
- multiple sclerosis
- liver failure
- type diabetes
- drug induced
- physical activity
- metabolic syndrome
- escherichia coli
- body mass index
- weight gain
- staphylococcus aureus
- risk assessment
- cystic fibrosis
- respiratory failure
- extracorporeal membrane oxygenation
- weight loss
- human health
- hepatitis b virus