Parents of Children With Nonsyndromic Orofacial Clefting Show Altered Palate Shape.

Ahmed M El SerganiStephanie BrandeburaCarmencita PadillaAzeez ButaliWasiu L AdeyemoConsuelo Valencia-RamírezClaudia P Restrepo MuñetonLina M MorenoCarmen J BuxóRoss E LongKatherine NeiswangerJohn R ShafferMary L MarazitaSeth M Weinberg

Published in: The Cleft palate-craniofacial journal : official publication of the American Cleft Palate-Craniofacial Association (2020)

Our findings suggest that altered palate shape is a subclinical phenotypic feature, which may be indicative of elevated orofacial cleft risk. The risk phenotype varied by sex and ancestry, suggesting possible etiologic heterogeneity among demographic groups. Understanding the genetic basis of these informative palate shape traits may reveal new genes and pathways relevant to nonsyndromic orofacial clefting.

Keyphrases

genome wide
machine learning
dna methylation
young adults
deep learning
copy number
transcription factor