Microduplication of 16p11.2 locus Potentiates Hypertrophic Obesity in Association with Imbalanced Triglyceride Metabolism in White Adipose Tissue.

Dilong WangQiuyan MaiXiuyan YangXinjin ChiRuohan LiJian JiangLiang LuoXiaoyi FangPeng YunLiyang LiangGuang YangKun SongLiang FangYun ChenYing ZhangYulong HeNingning LiYihang Pan

Published in: Molecular nutrition & food research (2022)

This study elucidates that the imbalanced TG synthesis/hydrolysis in adipocytic lipid droplets may contribute to the hypertrophic obesity and metabolic disorders in mice with 16p11.2 microduplication.

Keyphrases

high fat diet induced
insulin resistance
adipose tissue
metabolic syndrome
weight loss
type diabetes
weight gain
high fat diet
skeletal muscle
fatty acid
physical activity
low density lipoprotein