Anti-manic effect of deep brain stimulation of the ventral tegmental area in an animal model of mania induced by methamphetamine.

Roger B VarelaSuelen L BoschenNathanael YatesTristan HoughtonCharles D BlahaKendall H LeeKevin E BennetAbbas Z KouzaniMichael BerkJoao de QuevedoSamira S ValvassoriSusannah J Tye

Published in: Bipolar disorders (2024)

These results demonstrate that both VTA LFS and HFS DBS exert anti-manic effects and modulation of DA dynamics in the NAc. More specifically the increase in DA reuptake driven by increased DAT expression may serve as a potential mechanism by which VTA DBS exerts its anti-manic effects.

Keyphrases

deep brain stimulation
bipolar disorder
parkinson disease
obsessive compulsive disorder
poor prognosis
transcription factor
spinal cord
risk assessment