Effects of Diclofenac Etalhyaluronate (SI-613/ONO-5704) on Cartilage Degeneration in Arthritic Rats and Inflammatory Cytokine-Stimulated Human Chondrocytes.

Shuhei TakadaRisa NoderaKeiji Yoshioka

Published in: Cartilage (2024)

In this study, we demonstrated the chondroprotective effect of DEH in rats with collagen-induced arthritis and in interleukin-1β-stimulated human chondrocytes. Thus, DEH may suppress cartilage degeneration in patients with musculoskeletal diseases, such as OA.

Keyphrases

endothelial cells
extracellular matrix
high glucose
induced pluripotent stem cells
pluripotent stem cells
rheumatoid arthritis
oxidative stress
drug induced