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Targeting the Complement Cascade in the Pathophysiology of COVID-19 Disease.

Nicole NgCharles A Powell
Published in: Journal of clinical medicine (2021)
Severe coronavirus disease 2019 causes multi-organ dysfunction with significant morbidity and mortality. Mounting evidence implicates maladaptive over-activation of innate immune pathways such as the complement cascade as well as endothelial dysfunction as significant contributors to disease progression. We review the complement pathways, the effects of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) on these pathways, and promising therapeutic targets in clinical trials.
Keyphrases
  • respiratory syndrome coronavirus
  • sars cov
  • coronavirus disease
  • innate immune
  • clinical trial
  • oxidative stress
  • randomized controlled trial