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Altered extracellular matrix dynamics is associated with insulin resistance in adolescent children with obesity.

Aaron L SlusherJessica NouwsFuyuze TokogluAlla Vash-MargitaMarcy D MatthewsMark FitchMahalakshmi ShankaranMarc K HellersteinSonia Caprio
Published in: Obesity (Silver Spring, Md.) (2024)
Altered extracellular matrix dynamics, but not expandability, potentially decreases abdominal SAT lipid storage capacity, contributing to the pathophysiological pathways linking adipose tissue and whole-body IR with altered ectopic storage of lipids within the liver among IR adolescents with obesity.
Keyphrases
  • extracellular matrix
  • young adults
  • insulin resistance
  • adipose tissue
  • metabolic syndrome
  • weight loss
  • high fat diet induced
  • type diabetes
  • weight gain
  • high fat diet
  • mental health
  • physical activity
  • fatty acid