Identification of a potent and selective LAPTc inhibitor by RapidFire-Mass Spectrometry, with antichagasic activity.

Maikel IzquierdoDe LinSandra O'NeillLauren A WebsterChristy PatersonJohn ThomasMirtha Elisa AguadoEnrique Colina AraújoDaniel Alpízar-PedrazaHalimatu JojiLorna MacLeanAnthony HopeDavid W GrayMartin ZoltnerMark C FieldJorge González-BacerioManu De Rycker

Published in: PLoS neglected tropical diseases (2024)

Our data indicates that these new LAPTc inhibitors should be considered for further development as antiparasitic agents for the treatment of Chagas disease.

Keyphrases

mass spectrometry
liquid chromatography
electronic health record
big data
high performance liquid chromatography
machine learning
anti inflammatory
deep learning
solid phase extraction