Phenome-wide association analysis of LDL-cholesterol lowering genetic variants in PCSK9.
Amand Floriaan SchmidtMichael V HolmesDavid PreissDaniel I SwerdlowSpiros DenaxasGhazaleh FatemifarRupert FarawayChris FinanDennis ValentineZammy Fairhurst-HunterFernando Pires HartwigBernardo Lessa HortaElina HypponenChristine PowerMax MoldovanErik van IperenKees HovinghIlja DemuthKristina NormanElisabeth Steinhagen-ThiessenJuri DemuthLars BertramChristina M LillStefan CoassinJohann WilleitStefan KiechlKarin WilleitDan MasonJohn WrightRichard MorrisGoya WanametheePeter WhincupYoav Ben-ShlomoStela McLachlanJackie F PriceMika KivimakiCatherine WelchAdelaida Sanchez-GalvezPedro Marques-VidalAndrew NicolaidesAndrie G PanayiotouN Charlotte Onland-MoretYvonne T van der SchouwGiuseppe MatulloGiovanni FioritoSimonetta GuarreraCarlotta SacerdoteNicholas J WarehamClaudia LangenbergRobert A ScottJian'an LuanMartin BobakSofia MalyutinaAndrzej PająkRuzena KubinovaAbdonas TamosiunasHynek PikhartNiels GrarupOluf PedersenTorben HansenAllan LinnebergTine JessJackie CooperSteve E HumphriesMurray BrilliantTerrie KitchnerHakon HakonarsonDavid S CarrellCatherine A McCartyKirchner H LesterEric B LarsonDavid R CrosslinMariza de AndradeDan M RodenJoshua C DennyCara CartyStephen HancockJohn AttiaElizabeth HollidayRodney ScottPeter SchofieldMartin O'DonnellSalim YusufMichael ChongGuillaume ParePim van der HarstM Abdullah SaidRuben N EppingaNiek VerweijHarold Sniedernull nullTim ChristenD O Mook-Kanamorinull nullStefan GustafssonLars LindErik IngelssonRaha PazokiOscar FrancoAlbert HofmanAndre UitterlindenAbbas DehghanAlexander TeumerSebastian BaumeisterMarcus DörrMarkus M LerchUwe VölkerHenry VölzkeJoey WardJill P PellTom MeadeIngrid E ChristophersenAnke H Maitland-van der ZeeEkaterina V BaranovaRobin YoungIan FordArchie CampbellSandosh PadmanabhanMichiel L BotsDiederick E GrobbeePhilippe FroguelDorothée ThuillierRonan RousselAmélie BonnefondBertrand CariouMelissa SmartYanchun BaoMeena KumariAnubha MahajanJemma C HopewellSudha Seshadrinull nullCaroline DaleRui Providencia E CostaPaul M RidkerDaniel I ChasmanAlex P ReinerMarylyn D RitchieLeslie A LangeAlex J CornishSara E DobbinsKari HemminkiBen KinnersleyMarc SansonKarim LabrecheMatthias SimonMelissa BondyPhilip LawHelen SpeedyJames AllanNi LiMolly WentNiels WeinholdGareth MorganPieter SonneveldBjörn NilssonHartmut GoldschmidtAmit SudAndreas EngertMarkus HanssonHarry HemingwayFolkert W AsselbergsRiyaz S PatelBrendan J KeatingNaveed SattarRichard HoulstonJuan P CasasAroon D HingoraniPublished in: BMC cardiovascular disorders (2019)
Genetic variation at the PCSK9 locus recapitulates the effects of therapeutic inhibition of PCSK9 on major blood lipid fractions and MI. While indicating an increased risk of T2DM, no other possible safety concerns were shown; although precision was moderate.