High-fat diet aggravates postoperative cognitive dysfunction in aged mice.

Lan WeiMinmin YaoZhimeng ZhaoHui JiangShengjin Ge

Published in: BMC anesthesiology (2018)

HFD can aggravate POCD in aged C57BL/6 mice, an effect that may be related to the inhibition expression of Sirt1 and the promotion of neuronal apoptosis.

Keyphrases

high fat diet
insulin resistance
high fat diet induced
adipose tissue
oxidative stress
poor prognosis
patients undergoing
endoplasmic reticulum stress
cell death
metabolic syndrome
type diabetes
cell cycle arrest
ischemia reperfusion injury
brain injury
wild type
drug induced
pi k akt