Associations among smoking, MGMT hypermethylation, TP53-mutations, and relapse in head and neck squamous cell carcinoma.
Shinichi MatsudaAki MafuneNagisa KohdaTakanori HamaMitsuyoshi UrashimaPublished in: PloS one (2020)
It was found that hmMGMT was suppressed by heavy smoking, and hmMGMT combined with disruptive TP53-mutations may indicate a poor prognosis in patients with HNSCC.